Abstract
We present in this paper the case of a 12-year-old girl who had the clinical features
of 2 different disorders: neurofibromatosis 1 (NF1) and 3 hemangiomas located in the
skin, liver and mediastinum. The patient did not receive any specific treatment and
showed a normal progressive evolution that lasted 1 / to 2 years and a very slow regression
that lasted for a more prolonged time than expected (the 3 hemangiomas have not completely
disappeared yet), although all 3 have been asymptomatic. MRI of the brain did not
disclose a hemangioblastoma of the cerebellum or any other vascular lesion of the
brain. Mental development of this girl was in the borderline range, as is commonly
seen in Pascual-Castroviejo II syndrome (P-CIIS)/PHACE syndrome and in NF1, 2 syndromes
which have not been reported to be associated in the same patient previously.
Key words
Pascual-Castroviejo type II syndrome (P-CIIS) - PHACE - cutaneous hemangioma - hepatic
hemangioma - mediastinal hemangioma - neurocutaneous disorders
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Correspondence
Ignacio Pascual-Castroviejo
Private surgery
Pediatric Neurology
14 Orense Street
28020 Madrid
Spain
Phone: +34/91/555 0356
Fax: +34/91/623 6572
Email: i.pcastroviejo@neurologia.e.telefonica.net
